After the neural plate folds, which structure forms next in the process of neurulation?

The neural plate is the initial structure that forms during early embryonic development and gives rise to the nervous system. As neurulation begins, the neural plate undergoes a series of changes, first folding to create the neural groove. The neural groove is the indentation that forms along the center of the neural plate as the edges begin to elevate and fold upwards.

The next significant step in the process involves these elevated edges, known as the neural folds, coming together to eventually form the neural tube. However, the formation of the neural groove is a critical and immediate consequence of the folding process.

The neural crest and the neural tube are subsequent structures that form after the neural groove has established itself, guided by further development and fusion of the neural folds. The understanding of the sequence of structures is crucial in developmental biology, as abnormalities during these stages can lead to neural tube defects and other developmental issues.